The train was stopped on the tracks as the fire department detirmine if any passengers were injured.
At least 10 people were pictured being taken to the local hospital.
While travelling at high-speed the train struck a box truck on the tracks near Sunland Boulevard.
The Metrolink train, consists of six cars, hit the vehicle at around 10.40am local time.
Nearby roads will be shut down while officials investigate.
No serious injuries have been reported.
This same crossing has been the subject of a number of accidents in the past.
A Los Angeles Time article found there had been 13 accidents at the rail crossing at Sunland Boulevard.